Lawrence Harshman
Lawrence Harshman
Professor

Ph.D. State University of New York - Stony Brook, 1982
        (Ecology & Evolution)
M.S. University of California-Riverside, 1977
        (Biology)
B.S. University of California-Riverside, 1975
        (Biology)
Contact Information
335A Manter Hall
402.472.0680/0986

lharsh@unl.edu 

Research Interests


Larry Harshman investigates the genetic, physiological and other biological factors that underlie extended longevity of Drosophila melanogaster. The aging research is supported by NIH. His laboratory also studies stress resistance and aspects of reproduction of D. melanogaster.

Publications


  • Wang, Y., A.B. Salmon and L.G. Harshman*. 2001. A cost of reproduction: oxidative stress susceptibility is associated with increased egg production in Drosophila melanogaster. Experimental Gerontology 36: 1349-1359.
  • Salmon, A.B., D.B. Marx and L.G. Harshman*. 2001. A cost of reproduction in Drosophila melanogaster: stress susceptibility. Evolution 55: 1600-1608.
  • Clancy, D.J., D. Gems, L.G. Harshman, H.S. Oldham, E. Hafen, S.J. Leevers and L. Partridge. 2001. Extension of lifespan by CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106.
  • Zera, A.J. and L.G. Harshman. 2001 The physiology of life history trade-offs in animals. Annual Review Ecology and Systematics 32: 95-126.
  • Carey, J.R., P. Liedo, L. Harshman, Y. Zhang, J.-G. Muller, L. Partridge and J.-L. Wang. 2002. Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell 1: 140-148.
  • Harshman, L.G. 2003. Genetic research on aging and longevity of Drosophila melanogaster. Population and Development Review Vol. 29S: 99-126.
  • Richard, D.S., R Rybczynski, T.G. Wilson, Y. Wang, M.L. Wayne, Y. Zhou, T.R., L. Partridge and L.G. Harshman*. 2005. Insulin signaling is necessary for vitellogenesis in Drosophhila melanogaster independent of the roles of juvenile hormone and ecdysteroids: Female sterility of the chico1 insulin signaling mutation is autonomous to the ovary. Journal of Insect Physiology 51: 455-464.
  • Harshman, L.G., H.-G. Mueller, X. Liu, Yue Wang, James R. Carey. 2005. The symmetry of longevity. Jour. Gerontol. 60: 1233-1237.
  • Wang, M.H., L.G. Harshman and S.V. Nuzhdin. 2005. Quantitative trait loci for lipid content in Drsoophila melanogaster. Obesity Research 13: 1891-1897.
  • Wang, Y., Pott, D. Kachman, S., Nuzhdin, S.V. and L.G. Harshman*. 2006. Quantitative genetic analysis of oxidative stress resistance and early age egg production. Journal of Heredity 97: 355-366.
  • McIntyre, L.M., L. Bono, A. Genissel, R. Westerman, D. Junk, M. Telonis-Scott, L. Harshman, M.L. Wayne, A. Kopp, and S.V. Nuzhdin. 2006. Sex-specific expression of alternative transcripts in Drosophila. Genome Biology 7:R79
  • Kabil, H., Partridge, L. and L.G. Harshman*. Superoxide dismutase activity and oxidative stress. Survival in the long-lived chico1 mutation and in dietary restricted Drosophila melanogaster. Biogerontology (2006, published online ahead of print)
  • Harshman, L.G. and A.J. Zera. The cost of reproduction – the devil in the details. 2007. Trends in Ecology and Evolution (January volume)
  • Zera, A.J., L.G. Harshman, T. Williams. 2007. Evolutionary endocrinology: The developing synthesis between endocrinology and evolutionary genetics. Annu. Rev. Ecol. Systematics
  • Richard, D.S., Rybczynski, T.G. Wilson, Y. Wang, M.L. Wayne, Y. Zhou, T.R. Kroll, L. Partridge and L.G. Harshman*. Tissue autonomous inhibition of vitellogenic oocyte maturation by the chico1 insulin-signaling mutation of Drosophila melanogaster does not depend on changes in levels of systemic juvenile hormone or ecdysone (submitted MS)
  • Wayne, M.L., U. Soundararajan and L.G. Harshman*. Correlated responses to selection for female starvation resistance in Drosophila melanogaster: ovariole number and age-specific egg production. (submitted for publication)
  • Harshman, L.G., J.M. Vickers, V.K. Ward, B.C. Bonning, D.F. Grant, T. Shiotsuki, B.F. Eldridge and B.D. Hammock. 2003. In vitro metabolism of juvenile hormone in A. aegypti and biological activity of recombinant juvenile hormone esterase on female mosquitoes. Jour. Insect Physiol. (accepted for publication)
  • Harshman, L.G. 2003. Genetic research on aging and longevity of Drosophila melanogaster. Population and Development Review (in press)
  • Carey, J.R., P. Liedo, L. Harshman, Y. Zhang, J.-G. Muller, L. Partridge and J.-L. Wang. 2002. Life history response of Mediterranean fruit flies to dietary restriction. Aging Cell December
  • Carey, J.R., P. Liedo, L. Harshman, X. Liu, H.-G. Muller, L. Partridge and J.-L. Wang. 2002. Food pulses increase longevity and induce cyclical egg production in Mediterranean fruit flies. Functional Ecology 16: 313-325.
  • Carey, J.R., P. Liedo, L. Harshman, Y. Zhang, H.G. Muller, L. Partridge and J.L. Wang. 2002. A mortality cost of virginity at older ages in female Mediterranean fruit flies. Exp. Gerontol. 37: 507-512.
  • Zera, A.J., T. Sanger, J. Hanes and L.G. Harshman. 2002. Purification and characterization of hemolymph juvenile hormone esterase from the cricket, Gryllus assimilis. Archives of Insect Biochem. Physiol. 49: 41-55.
  • Zera, A.J. and L.G. Harshman. 2001 The physiology of life history trade-offs in animals. Annual Review Ecology and Systematics 32: 95-126.
  • Clancy, D.J., D. Gems, L.G. Harshman, H.S. Oldham, E. Hafen, S.J. Leevers and L. Partridge. 2001. Extension of lifespan by CHICO, a Drosophila insulin receptor substrate protein. Science 292: 104-106.