Lawrence Harshman

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Professor Biological Sciences 402-472-0680 Manter Hall 335

Research Interests

I investigate the genetic, physiological and other biological factors that underlie extended longevity of Drosophila melanogaster. My laboratory also studies stress resistance and aspects of reproduction of D. melanogaster.

Recent Publications

  • Lee, B.C., A. Kaya, S. Ma, B. Kim, M.V. Gerashenenko, S.H. Yim, Z. Hu, L.G. Harshman and V.N. Gladyshev, V.N.  2014.  Methionine restriction extends lifespan of Drosophila melanogaster under condition of low amino acid status. Nature Communications 5 (article number: 3592) 
  • Scheitz, C.J.F., Y. Guo, A.M. Early , L.G. Harshman and A.G. Clark. 2013. Heritability and inter-population differences in lipid profiles in Drosophila melanogaster. PLOS ONE 0072726
  • Ma, J., A.K. Benson, S.D. Kachman, Z. Hu and L.G. Harshman. 2012. Drosophila melanogaster selection for survival of Bacillus cereus infection: life history trait indirect responses.  International Journal of Evolutionary Biology. Article ID 935970: 12 pp.
  • Tyrone A.M., L.M. McIntyre, L.G. Harshman and S.V. Nuzhdin. 2012.  Genetic Variation in the Yolk protein expression network of Drosophila melanogaster Negatively correlates with longevity and differentially influences the sexes. Heredity 109:226-234.
  • Schwasinger-Schmidt T.E., S.D. Kachman and L.G. Harshman. 2012. Evolution of starvation resistance in Drosophila melanogaster: measurement of direct and correlated responses to artificial selection.  Jour. Evol. Biol. 25: 378-387.
  • Greenberg, A.J., S.R. Hackett, L.G. Harshman and A.G. Clark. 2011. Environmental and genetic perturbations reveal different networks of metabolic regulation. Molecular Systems Biology 7: 563.
  • Kabil, H. O. Kabil, R. Banerjee, L.G. Harshman and S.D. Pletcher.  2011. Increased transsulfuration mediates longevity and dietary restriction in Drosophila. Proc. Natl. Acad. Sci. USA 108: 16831-16836.
  • Shchedrina, V.A., H. Kabil, G. Vorbruggen, B.C. Lee, A.A. Turanov, M. Hirosawa-Takamori, H..-Y. Kim, L.G.Harshman, D.L Hatfield and V.N. Gladeshev. 2011. Analyses of fruit flies that do not express selenoproteins or express a mouse selenoprotein, methionine sulfoxide reductase B1, reveal of role of selenoproteins in stress resistance.  Jour. Biol. Chem. 286: 29449-29461.
  • Greenberg, A.R., S.R. Hackett, L.G. Harshman and A.G. Clark. 2010. A hierarchical Bayesian model for a novel sparse diallel crossing scheme. Genetics 185:361-373.
  • Lawrence G. Harshman, Ki-Duck Song, Josephina Casas, A. Schurmans, Eichii Kuwano, Stephen D. Kachman, Lynn M. Riddiford, Bruce D. Hammock. 2010. Bioassays of compounds with potential juvenoid activity on Drosophila melanogaster: Juvenile hormone III, bisepoxide juvenile hormone III and methyl farnesoates. Journal of Insect Physiology 56:1465-1470.
  • Prokupek, A.M., S.-E. Eyun, L. Ko, E. Moriyama and L.G. Harshman.  2010. Molecular evolution of seminal receptacle sperm storage organ genes of Drosophila melanogaster. Journal of Evolutionary Biology 23:1386-1398.
  • Prokupek, A.M., S.D. Kachman, I. Ladunga and L.G. Harshman.  2009. Transcriptional profiling of the sperm sperm storage organs of Drosophila melanogaster. Insect Molecular Biology 18:465-475.
  • Zera, A.J. and L.G. Harshman. 2010. Intermediary metabolism and the biochemical-molecular basis of life history evolution and trade-offs in two insect models.  In  "Molecular Mechanisms of Life History Evolution", T. Flatt and A. Heyland (eds.). Oxford University Press.
  • Shchedrina, V.A., G. Vorbruggen, B.C. Lee, H.Y. Kim, H. Kabil, L.G. Harshman, and V.N. Gladeshev.  2009. Overexpression of methionine-R-sulfoxide reductaseshas no influence on fruit fly aging.  Mech. Ageing Dev. 130:429-443.
  • Nuzhdin, S.V., A. Pickering, J.A. Brisson, M.L. Wayne, L.G. Harshman and L.M. McIntyre.  2009.  Natural genetic variation in transcriptome reflects networkstructure inferred with major effect mutations: insulin/TOR and associated phenoytypes in Drosophila melanogaster.  BMC Genomics 10.
  • Zera, A.J. and L.G. Harshman. 2009. Laboratory selection studies of life-history physiology in insects. In "Experimental Evolution", T. Garland Jr. and M.R. Rose(eds). University of California Press.
  • Prokupek, A., F. Hoffmann, S. Eyun, E. Moriyama, E. Moriyama, M. Zhou and L. Harshman. 2008. An evolutionary expressed sequence tag analysis ofDrosophila spermatheca genes. Evolution 62: 2936-2947.
  • Carey, J.R., L.G. Harshman, P. Liedo, H.-G. Mue ller, J.-L. Wang and Z. Zhang. 2008.  Longevity-fertility trade-offs in the tephritid fly, Anastrepha ludens.Ageing Cell 7:470-47.
  • Smith, E.M., Hoi, J.T., Eissenberg, J.C. Shoemaker, J.D., Nackameyer, W.S., Ilvarson, A.M., Harshman, L.G., Schegel, V.L. and J. Zempleni.  2007. Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and life span, and alters gene expression and histone biotinylation patterns. J. Nutr. 137:2006-2012.
  • Wayne, M.L., M. Telonis-Scott, L. Bono, L.G. Harshman, L.M. McIntyre, A. Kopp, and S.V.  Nuzhdin.  2007. Simpler mode of inheritance of transcriptional variation in male Drosophila melanogaster. P.N.A.S. U.S.A. 104: 18577-18582.
  • Zera, A.J., L.G. Harshman, T. Williams.  2007. Evolutionary endocrinology: The developing synthesis between endocrinology and evolutionary genetics. Annu. Rev. Ecol. Evol. Systematics 38: 793-817.
  • Smith, E.M., J.T. Hoi, J.C. Eissenberg, J.D. Shoemaker, W.S. Neckameyer, Ilvarsonn, A.M., L.G. Harshman, Schlegel, V.L. and J. Zempleni. 2007. Feeding Drosophila a biotin-deficient diet for multiple generations increases stress resistance and alters gene expression and histone biotynylation patterns. The Journal of Nutrition 137: 2006-2012.
  • Crone, E.J., A.J. Zera, A. Anand, J.G. Oakeshott, T.D. Sutherland, R.J. Russell, L.G. Harshman, F.G. Hoffmann and C. Claudianos. 2007.  Jhe in Gryllus assimilis:cloning, sequence-activity  associations and phylogeny. Insect Biochemistry and Molecular Biology 37: 1359-1365.
  • Nuzhdin, S.V., L.G. Harshman, M. Zhou and K. Harmon. 2007.  Genome enabled hitch-hiking mapping identifies alleles for stress resistance in laboratory selected Drosophila from a natural population. Heredity 99: 313-321.
  • Harshman, L.G. and A.J. Zera.  2007. The cost of reproduction – the devil in the details. Trends in Ecology and Evolution 22: 80-86.
  • Kabil, H., Partridge, L. and L.G. Harshman. 2006. Superoxide dismutase activity and oxidative stress survival in the long-lived chico mutation and in dietary restricted Drosophila melanogaster. Biogerontology 8: 201-208.
  • Wayne, M.L., U. Soundararajan and L.G. Harshman.  2006. Correlated responses to selection for female starvation resistance in Drosophila melanogaster: ovariole number and age-specific egg production. Biomed Central Evolutionary Biology 6:57
  • McIntyre, L.M., L. Bono, A. Genissel, R. Westerman, D. Junk, M. Telonis-Scott, L. Harshman, M.L. Wayne, A. Kopp, and S.V. Nuzhdin.  2006. Sex-specific expression of alternative transcripts in Drosophila. Genome Biology 7:R79
  • Wang, Y., Pott, D. Kachman, S., Nuzhdin, S.V. and L.G. Harshman.  2006. Quantitative genetic analysis of oxidative stress resistance and early age egg production.  Journal of Heredity 97: 355-366.
  • Genetic and Physiological Factors of Drosophila Melanogaster
  • Ph.D. State University of New York at Stony Brook
  • M.S. University of California, Riverside
  • B.S. University of California, Riverside