Qingsheng Li
Qingsheng Li
Associate Professor
Faculty
Ph D
Contact Information
305 Morrison, Nebraska Center for Virology
402-472-5922

 

Research Interests

Qingsheng’s research focuses on better understanding the interaction of human immunodeficiency virus type-1 (HIV-1) with its host in the earliest infection to elucidate key steps and critical events in the mucosal transmission of HIV-1, to identify correlates of protection, and ultimately to develop an effective anti-viral topical microbicide and vaccine. 

Grants:

R01 DK087625-01 8/15/2010-08/14/2014

NIH (Li, Q, PI) $ 1,273,641

The Early Events Determining SIV Rectal Transmission

Qingsheng Li, PI, subcontract with DAIDS, NIAID, title: “Transcriptome study of SIV rectal transmission in rhesus macaques”, started 08/2010, 2 year, $ 160,000.

Qingsheng Li, awarded: subcontract PI with Dr. Luis Montaner of the Wistar Institute, title:” Cellular innate activation as a tactic to prevent HIV-1 transmission”, 2010-2011. $ 50,000

Pending:

Qingsheng Li PI, R01, entitled: “Mechanisms and prevention of sexual transmission of HIV/SIV", requested period: 03/01/2011-02/29/2016, requested amount: $ 2,668,488

Qingsheng Li, subcontract PI, Sponsor: Wistar Institute, entitled “Early innate/IgA anti-HIV/SIV”, requested period: 03/01/2011-02/29/2016, and requested amount: $ 44,500/year

Qingsheng Li, subcontract PI, sponsor: Emory University, entitled” B-cell biology of mucosal immune”, requested period: 07/01/2014 - 06/30/2016, and requested amount: $ 105,183

Qingsheng Li, one of the PIs in P01 grant, entitled: “immunological barrier to vaginal SIV transmission” Requested period: 7/01/11-6/30/16, requested amount for Li: $ 2,849,000

Publications

  • Smith A. J., Q. Li, S.W. Wietgrefe, et al. Host Genes Associated with HIV-1 Replication in Lymphatic Tissue. J. Immunol. 2010,185:5417-24.
  • García A, N.B. Siddappa, Q. Li, et al. AIDS and optic neuritis in a rhesus monkey infected with the R5 clade C SHIV-1157ipd3N4. J Med Primatol. 2010, 39:356–360, PMID- 20412378
  • Yukl, SA.l, S. Gianella,.E. Sinclair, L. Epling, Q. Li, et al. Differences in HIV Burden and Immune Activation within the Gut of HIV Positive Patients Receiving Suppressive Antiretroviral Therapy. J. Infect. Dis. 2010, 202:1553–1561.
  • Li, Q., J.D. Estes, P.M. Schlievert, et al. Glycerol monolaurate prevents mucosal SIV transmission. Nature 2009 458: 1034-1038. PMCID: PMC2785041
  • Li, Q., P.J. Skinner, S.-J. Ha, et al. Visualizing antigen-specific and infected cells in situ predicts outcomes in early viral infection. Science 2009 323: 1726-1729. PMCID: PMC2753492
  • Bosinger, SE., Q. Li, SN. Gordon, et al. Global genomic analysis reveals rapid control of a robust innate response in SIV-infected sooty mangabeys. J. Clin. Invest. 2009, 119:3556–3572. PMCID:PMC2786806. (Bosinger, SE. and Li Q. are co-first-authorship with equal contribution).
  • Li, Q., A.J. Smith, T.W. Schacker, J.V. Carlis, L. Duan, C.S. Reilly, and A.T. Haase. Microarray analysis of lymphatic tissue reveals stage-specific, gene-expression signatures in HIV-1 infection. J. Immunol. 2009, 183: 1975–1982.
  • Li Q, J. Skinner P, Duan L, Haase AT. A technique to simultaneously visualize virus-specific CD8+ T Cells and Virus-Infected Cells In situ. J. Vis. Exp. 2009 Aug 13;(30)
  • Li, Q., J.D. Estes, L. Duan, J. Jessurun, S. Pambuccian, C. Forster, S. Wietgrefe, M. Zupancic, T. Schacker, C. Reilly, J.V. Carlis, and A.T. Haase. Simian immunodeficiency virus-induced intestinal cell apoptosis is the underlying mechanism of the regenerative enteropathy of early infection. J. Infect. Dis. 2008, 197:420-429.
  • Weiler, A.M., Q. Li, L. Duan, et al. Genital ulcers facilitate rapid viral entry and dissemination following intravaginal inoculation with cell-associated simian immunodeficiency virus SIVmac239. J. Virol. 2008 82: 4154-4158. PMCID PMC2292998
  • Estes, J.D., Q. Li, M.R. Reynolds, et al. Premature induction of an immunosuppressive T regulatory response in acute SIV infection. J. Infect. Dis. 2006, 193:703-712.
  • Li, Q., L. Duan, J.D. Estes, et al. Peak SIV replication in “resting” memory CD4+ T cells depletes gut lamina propria CD4+ T cells. Nature 2005, 434:1148-1152.
  • Miller, C.J., Q. Li, K. Abel, et al. Propagation and dissemination of infection after vaginal transmission of SIV. J. Virol. 2005 79: 9217-9227.
  • Li, Q., J.D. Lifson, L. Duan, et al. Potential roles for follicular dendritic cell associated osteopontin in lymphoid follicle pathology and repair and B cell regulation in HIV-1 and SIV infections. J. Infect. Dis. 2005, 192:1269-1276.
  • Zhang, Z.-Q., S.W. Wietgrefe, Q. Li, et al. Roles of substrate availability and infection of resting and activated CD4+ T cells in transmission and acute simian immunodeficiency virus infection. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:5640-5645.
  • Li, Q., K.G. Mansfield, A.A. Lackner, et al. Quantitative image analysis of simian immunodeficiency virus replication in macrophages co-infected with Mycobacterium avium complex. J. Infect. Dis. 2000, 181:867-871.
  • Li, Q., K. Gebhard, T. Schacker, et al. The relationship between tumor necrosis factor and human immunodeficiency virus gene expression in lymphoid tissue. J. Virol. 1997 71:7080-7082.