Ph.D. University of Florida - 1986
305 Beadle Center
My laboratory investigates the role of nuclear genes in the maintenance of organelle functional stability and signaling in plants. Our studies focus on chloroplast and mitochondrial genome maintenance processes, organellar protein targeting, and organellar influences on cell and plant phenotype. Phenotypic plasticity conditions plant adaptation to its environment, and both chloroplast and mitochondria influence these plant properties through their ability to serve as environmental sensors. Epigenetic changes within the plant to reprogram growth and development are likewise influenced by organelle properties. Our laboratory seeks to understand how mitochondrial and chloroplast signals alter plant phenotype and epigenetic properties of the plant in response to environmental cues. We also study how these intriguing cellular signals are transmitted to a plant's progeny.
Xu YZ, Arrieta-Montiel MP, Virdi K, De Paula WBM, Widhalm JR, Basset GJ, Davila JI, Elthon TE, Elowsky CG, Sato SJ, Clemente TE, Mackenzie SA 2011. MSH1 is a nucleoid protein that alters mitochondrial and plastid properties and plant response to high light. Plant Cell, Sept 20. Epub ahead of print. DOI 10.1105/tpc.111.089136
Arrieta-Montiel M. and Mackenzie, S.A. 2011. Plant Mitochondrial Genomes and Recombination, in: Advances in Plant Biology, Vol I. Plant Mitochondria (F. Kempken, ed). Springer Publ. pp. 65-84.
Mackenzie, S.A. 2011. Male Sterility in Plants, In: Plant Biotechnology and Agriculture: Prospects for the 21st century, A. Altman and P.M. Hasegawa eds., Elsevier Press.
Davila JI, Arrieta-Montiel MP, Wamboldt Y, Shedge,V, Xu Y-Z, Mackenzie SA. 2011 Double-strand break repair processes drive evolution of the mitochondrial genome in Arabidopsis. BMC Biology 9(1):64.
Shedge V, Davila J, Arrieta-Montiel MP, Mohammed S, Mackenzie SA. 2010. Extensive rearrangement of the Arabidopsis mitochondrial genome elicits cellular conditions for thermotolerance. Plant Physiol. 152:1960-70.
Wamboldt, Y., Mohammed, S., Elowsky, C., Wittgren, C., de Paula, W. and Mackenzie S. 2009. Alternative translation initiation leads to differentially targeted protein isoforms in Arabidopsis. Plant Cell 21:157-67
Arrieta-Montiel MP, Shedge V, Davila J, Christensen AC, Mackenzie SA. 2009. Diversity of the Arabidopsis mitochondrial genome occurs via nuclear-controlled recombination activity. Genetics 183:1261-8.
Shedge, V., Arrieta-Montiel, M., Christensen, A.C. and Mackenzie, S.A. 2007. Plant Mitochondrial Recombination Surveillance Requires Unusual RecA and MutS Homologs. Plant Cell 19, 1251-1264.
Sandhu, A.P., Abdelnoor, R.V., and Mackenzie, S.A. 2007. Transgenic induction of mitochondrial rearrangements for cytoplasmic male sterility in crop plants. Proc Natl Acad Sci U S A 104, 1766-1770
Abdelnoor, R.V., Christensen, A.C., Mohammed, S., Munoz-Castillo, B., Moriyama, H. and Mackenzie, S.A. 2006. Mitochondrial genome dynamics in plants and animals: Convergent gene fusions of a MutS homolog. J Mol Evol. 63:165-73
Mackenzie SA. 2005. Plant organellar protein targeting: a traffic plan still under construction. Trends Cell Biol. 10:548-54.
Christensen AC, Lyznik A, Mohammed S, Elowsky CG, Elo A, Yule R, Mackenzie SA. 2005. Dual-domain, dual-targeting organellar protein presequences in Arabidopsis can use non-AUG start codons. Plant Cell 10:2805-16.
Mackenzie, S.A.,2005. The influence of mitochondrial genetics on crop breeding strategies. Plant Breeding Reviews Vol 25:115-138. John Wiley and Sons
Mackenzie, S.A, 2005. The mitochondrial genome of higher plants: A target for natural adaptation. Diversity and Evolution of Plants, R. J. Henry, ed. CABI Publishers, Oxon, UK. Pp. 69-80.