Peter Angeletti

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Professor Biological Sciences pangeletti2@unl.edu 402-472-3986 Morrison Center 237

Research Interests

Dr. Angeletti’s work is focused on the replication and pathogenesis of human papillomaviruses (HPVs). His recent collaborative studies investigate the role of multi-HPV genotype infections on cervical dysplasia in HIV-positive Tanzanian women. In further studies, Dr. Angeletti’s lab discovered that certain bacterial families within the cervical microbiome (such as Mycoplasma), are associated with high-grade cervical dysplasia. His team is now investigating chronic inflammation induced by microbial dysbiosis as a key trigger for the progression of cervical neoplasias. In another study, his lab is researching the cause of ocular surface squamous neoplasia (OSSN), which is the sixth most common cancer among HIV-positive Zambians. The goal of these studies is to determine whether DNA tumor viruses have a role in the initiation and progression of the aggressive forms of this disease.

 

Recent Publications

  • Peter Julius, Stepfanie N. Siyumbwa, Phyllis Moonga, Fred Maate, Trevor Kaile, Gleb Haynatski Veenu Minhas, Jazmine Snow, Kristen Peterson, Patience Gihozo, Sam Streeter, Salan Kaur, Annika Evans, Kandali Samwel, Guobin Kang, John T. West, Charles Wood and Peter C. Angeletti*  Epstein Barr Virus, but Not Human Papillomavirus, is Associated with Preinvasive and Invasive Ocular Surface Squamous Neoplasias in Zambian Patients. Frontiers in Oncology. Vol 12, (2022).

  • Julius P, Siyumbwa SN, Moonga P, Maate F, Kaile T, Kang G, West JT, Wood C, Angeletti PC. Clinical and Pathologic Presentation of Primary Ocular Surface Tumors among Zambians. Ocul Oncol Pathol. 2021 Mar;7(2):108-120. PMID: 33869164

  • Klein, C. Samwel ,K. Kahesa, C. Mwaiselage, J. West, JT. Wood, C. Angeletti, PC. Mycoplasma Co-Infection Is Associated with Cervical Cancer Risk. Cancers (Basel). 2020 Apr 28;12(5):1093.

  • Klein, C. Kahesa, C. Mwaiselage, J. West, JT. Wood, C. Angeletti, PC. How the Cervical Microbiota Contributes to Cervical Cancer Risk in Sub-Saharan Africa.  Frontiers in Cellular and Infectious Microbiol. 2020 Feb 12;10:23. PMID: 32117800

  • He, C., Lv, X., Huang, C., Hua, G., Ma, B., Chen, X., Angeletti, P.C., Dong, J., Zhou, J., Wang, Z., Rueda, B., Davis, J., and Wang, C.  YAP1-LATS2 feedback loop dictates senescent or malignant cell fate to maintain tissue homeostasis. EMBO Reports. 2019 Mar;20(3). PMID: 30755404

  •  He, C. Lv, X., Huang, C., Angeletti, P. C., Hua, G., Dong, J., Zhou, J., Wang, Z., Ma, B. Chen, X., Lambert, P. F. Rueda B.R., Davis, J. S., and Wang, C.A A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports 2019 Mar 5;26(10):2636-2650. PMID:30840887

  • Klein, C., Gonzalez, D., Samwel, K. Kahesa, C., Mwaiselage, J., Aluthge,N., Fernando, S., West, J.T., Wood, C., and Angeletti P.C. Relationship Between the Cervical Microbiome, HIV Status, and Pre-Cancerous Lesions. mBio, 2019 Feb 19;10(1). PMID:30782659

  • Samwel K, Kahesa C, Mwaiselage J, Gonzalez D, West JT, Wood C, Palefsky J, Angeletti PC.  Analytical performance of a low-cost multiplex polymerase chain reaction human papillomavirus genotyping assay for use in Sub-Saharan Africa.  J Med Virol. 2018 Oct 22. PMID: 30281790. 

Specialization:

  • Replication and pathogenesis of human papillomaviruses (HPVs) and other DNA tumorviruses.

Links:
Education:
  • Ph.D. University of Alabama-Birmingham
  • M.S. Illinois State University
  • B.S. University of California-Los Angeles